John Zhang, MD, PhD, MSc


A true pioneer in the area of minimally invasive (Natural Cycle and Mini-IVF™) fertility care, Dr. John Zhang founded New Hope Fertility Center in 2004, and has since opened locations in China, Russia, and Mexico.
Since opening, Dr. Zhang has been behind several notable achievements in the area of assisted reproductive technology (ART), including the birth of a child by a 49 year-old using her own eggs, helping to restore a young woman’s fertility through a recent ovarian tissue transplant surgery in February of 2012, and being named one of New York’s Top Doctors in 2011.
Dr. Zhang completed his medical degree in at the Zhejiang University School of Medicine, and subsequently received his Master’s Degree at Birmingham University in the UK. In 1991, Dr. Zhang earned his Ph.D. in In-Vitro Fertilization (IVF), and, after studying and researching the biology of mammalian reproduction and human embryology for nearly ten years, became the first Fellow in the Division of Reproductive Endocrinology and Infertility of New York University’s School of Medicine in 2001.
Today, Dr. Zhang continues his research in non-embryonic stem cell research, long-term cryopreservation of oocytes, and oocyte (human egg cell) reconstruction by nuclear transfer. He is currently one of a handful of reproductive endocrinologists in the United States to hold a Ph.D. in embryology while also being certified as a high complexity lab director.

Research Publications


Zhang, J. (2016). Pregnancy derived from human zygote pronuclear transfer in a patient who had arrested embryos after IVF. ReprodBiomed Online. Aug 1.
Zhang J, Liu H. (2015). Cytoplasm replacement following germinal vesicle transfer restores meiotic maturation and spindle assembly inmeiotically arrested oocytes. Reprod Biomed Online. Apr 16.
Zhang, J., Zhuang, G., Zeng, Y., Acosta, C., Shu, Y., and Grifo, J. Pregnancy derived from human nuclear transfer. Fertl Steril 80, 56.
Liu, H., Chang, H.C., Zhang, J., Grifo, J., and Krey, L.C. (2003). Metaphase II nuclei generated by germinal vesicle transfer in mouse oocytessupport embryonic development to term. Hum Reprod, 18, 1903-1907.
Zhang, J., Shu, Y.M., Kret, L.C., Liu, H., Zhuang, G.L., and Grifo, J. (2002). In vitro development of human triploid zygotes reconstructed by pronuclear transfer. Fertil Steril 785, 180-181.
Liu, H., Krey, L.C., Zhang, J., Chang, H., and Grifo, J. (2002). Germinal vesicle xeno-transfer between mouse and human oocytes: A model to study ooplasmic influences on meiotic division. Fertil Steril, 78, S77.
Moffa, F., Conioglio, F., Krey, L.C., Grifo, J.A., Revelli, A., Massobrio, M., and Zhang, J. (2002). Germinal vesicle transfer between fresh andcryopreserved immature mouse oocytes. Hum Reprod, 17, 178-183.
Liu, H., Zhang, J., Krey, L.C., and Grifo, J. A. (2000). In-vitro development of mouse zygotes following reconstruction by sequential transfer of germinal vesicles and haploid pronuclei. Hum Reprod 15, 1997-2001.
Liu, H., Wang, C.W., Grifo, J.A., Krey, L.C., and Zhang, J. (1999). Reconstruction of mouse oocytes by germinal vesicle transfer: maturity ofhost oocyte cytoplasm determines meiosis. Hum Reprod14, 2357-2361.
Zhang, J., Wang, C.W., Gilfo, J., Adler, A., and Krey, L. (1999). In vitro maturation of human preovulatory oocytes following reconstruction by germinal vesicle transfer. Fertil Steril 71, 726-731.
Zhang, J., Blaszczyk, A., Grifo, J., Li, L., Licciardi, F., Noyes, N., and Krey, L (1997). Reconstruction of human MII oocytes by partialcytoplasmic substitution. Fertil Steril 68, S154.
Zhang, J. (2016). Pregnancy derived from human zygote pronuclear transfer in a patient who had arrested embryos after IVF. ReprodBiomed Online. Aug 1.
Zhang J, Liu H. (2015). Cytoplasm replacement following germinal vesicle transfer restores meiotic maturation and spindle assembly inmeiotically arrested oocytes. Reprod Biomed Online. Apr 16.
Zhang, J., Zhuang, G., Zeng, Y., Acosta, C., Shu, Y., and Grifo, J. Pregnancy derived from human nuclear transfer. Fertl Steril 80, 56.
Liu, H., Chang, H.C., Zhang, J., Grifo, J., and Krey, L.C. (2003). Metaphase II nuclei generated by germinal vesicle transfer in mouse oocytessupport embryonic development to term. Hum Reprod, 18, 1903-1907.
Zhang, J., Shu, Y.M., Kret, L.C., Liu, H., Zhuang, G.L., and Grifo, J. (2002). In vitro development of human triploid zygotes reconstructed by pronuclear transfer. Fertil Steril 785, 180-181.
Liu, H., Krey, L.C., Zhang, J., Chang, H., and Grifo, J. (2002). Germinal vesicle xeno-transfer between mouse and human oocytes: A model to study ooplasmic influences on meiotic division. Fertil Steril, 78, S77.
Moffa, F., Conioglio, F., Krey, L.C., Grifo, J.A., Revelli, A., Massobrio, M., and Zhang, J. (2002). Germinal vesicle transfer between fresh andcryopreserved immature mouse oocytes. Hum Reprod, 17, 178-183.
Liu, H., Zhang, J., Krey, L.C., and Grifo, J. A. (2000). In-vitro development of mouse zygotes following reconstruction by sequential transfer of germinal vesicles and haploid pronuclei. Hum Reprod 15, 1997-2001.
Liu, H., Wang, C.W., Grifo, J.A., Krey, L.C., and Zhang, J. (1999). Reconstruction of mouse oocytes by germinal vesicle transfer: maturity ofhost oocyte cytoplasm determines meiosis. Hum Reprod14, 2357-2361.
Zhang, J., Wang, C.W., Gilfo, J., Adler, A., and Krey, L. (1999). In vitro maturation of human preovulatory oocytes following reconstruction by germinal vesicle transfer. Fertil Steril 71, 726-731.
Zhang, J., Blaszczyk, A., Grifo, J., Li, L., Licciardi, F., Noyes, N., and Krey, L (1997). Reconstruction of human MII oocytes by partialcytoplasmic substitution. Fertil Steril 68, S154.